A New Classification of Amino Acids and Newer Methodology for Protein Function Prediction
نویسندگان
چکیده
One of the challenging tasks in protein science is function determination, as coded its amino acid sequence. At present, pace sequencing far ahead annotation, i.e., assignment. Surprisingly, conventional views acids are appearing to be hindering this task. In study, we find that current acids, both evolutionary and chemical, seen incomplete conveying their function. This study highlights an alternative perspective called New Chemical Logic (NCL) on chemical nature appears worthy further investigation prediction. based stereochemical properties. There numerous methods classify which classification describes best proteins unanswered question. While interesting problem itself, annotation not but methods. BLAST one such most popular method detect homologs assign Function, however, ultimately must explained terms. Thus, it pertinent ask what for classifying efficiently captures they make. To proceed theme, some well-known textbook classifications have been considered together with NCL. These integrated mask predict compared results. The NCL outperform other classifications.
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2021
ISSN: ['0006-3495', '1542-0086']
DOI: https://doi.org/10.1016/j.bpj.2020.11.1711